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Mol Med Rep. 2014 Sep;10(3):1448-54. doi: 10.3892/mmr.2014.2378. Epub 2014 Jul 14.

Bone marrow mesenchymal stem cells improve myocardial function in a swine model of acute myocardial infarction.

Author information

1
Clinical Molecular Biology Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
2
TEDA International Cardiovascular Hospital and Nankai University Medical College, Tianjin 300457, P.R. China.
3
Central Research Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Abstract

The aim of the current study was to confirm the effect and elucidate the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute myocardial infarction (AMI). AMI was induced in mini‑swine by ligating the left anterior descending coronary artery, and BMSCs (1x107) were injected via a sterile microinjection into the ischemic area. Six months postoperatively, electrocardiograph‑gated single photon emission computed tomography revealed that the myocardial filling defect was reduced and the left ventricular ejection fraction was improved in the BMSC group compared with the control group (P<0.05). Histopathological examination indicated that, in the BMSC treatment group, the percentage of survived myocardial tissue and the vessel density were increased, and the percentage of apoptosis was decreased compared with controls (P<0.05). Reverse transcription‑polymerase chain reaction results indicated that the expression levels of multiple inflammatory factors were significantly upregulated in the BMSC group compared with levels in the control group (P<0.05). In conclusion, the present study demonstrated that BMSC injection significantly improved cardiac function and reduced infarct size in six months, indicating that this method may be valuable for future study in clinical trials.

PMID:
25060678
DOI:
10.3892/mmr.2014.2378
[Indexed for MEDLINE]
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