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J Neuroimaging. 2015 May-Jun;25(3):460-4. doi: 10.1111/jon.12154. Epub 2014 Jul 25.

Altered Brain White Matter Integrity in Temporal Lobe Epilepsy: A TBSS Study.

Author information

1
Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, China.

Abstract

BACKGROUND AND PURPOSE:

The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS).

METHODS:

Twenty TLE patients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS.

RESULTS:

TLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain.

CONCLUSIONS:

TLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.

KEYWORDS:

Temporal lobe epilepsy; tract based spatial statistics; white matter integrity

PMID:
25060634
DOI:
10.1111/jon.12154
[Indexed for MEDLINE]

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