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J Perinatol. 2015 Jan;35(1):67-71. doi: 10.1038/jp.2014.135. Epub 2014 Jul 24.

Critical congenital heart disease screening by pulse oximetry in a neonatal intensive care unit.

Author information

1
1] Divisions of Cardiology, State University of New York at Buffalo, Buffalo, NY, USA [2] Clinical Epidemiology and Biostatistics (Health-Research Methodology), McMasters University, Hamilton, ON, Canada.
2
Division of Neonatal-Perinatal Medicine, Women and Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, NY, USA.

Abstract

OBJECTIVE:

Critical congenital heart disease (CCHD) screening is effective in asymptomatic late preterm and term newborn infants with a low false-positive rate (0.035%). (1) To compare 2817 neonatal intensive care unit (NICU) discharges before and after implementation of CCHD screening; and (2) to evaluate CCHD screening at <35 weeks gestation.

STUDY DESIGN:

Collection of results of CCHD screening including pre- and postductal pulse oximetry oxygen saturation (SpO2) values.

RESULT:

During the pre-CCHD screen period, 1247 infants were discharged from the NICU and one case of CCHD was missed. After 1 March 2012, 1508 CCHD screens were performed among 1570 discharges and no CCHDs were missed. The pre- and postductal SpO2 values were 98.8 ± 1.4% and 99 ± 1.3%, respectively, in preterm and 98.9 ± 1.3% and 98.9 ± 1.4%, respectively, in term infants. Ten infants had false-positive screens (10/1508 = 0.66%).

CONCLUSION:

Performing universal screening in the NICU is feasible but is associated with a higher false-positive rate compared with asymptomatic newborn infants.

PMID:
25058746
PMCID:
PMC4281287
DOI:
10.1038/jp.2014.135
[Indexed for MEDLINE]
Free PMC Article

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