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Drug Discov Today. 2014 Sep;19(9):1498-502. doi: 10.1016/j.drudis.2014.07.009. Epub 2014 Jul 21.

The emerging role of speckle-type POZ protein (SPOP) in cancer development.

Author information

1
Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA; Department of Urology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: ram.mani@utsouthwestern.edu.

Abstract

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.

PMID:
25058385
PMCID:
PMC4237012
DOI:
10.1016/j.drudis.2014.07.009
[Indexed for MEDLINE]
Free PMC Article
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