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Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):961-4.

[Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses].

[Article in Chinese]

Author information

1
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. E-mail: zzb24@sina.com.cn.

Abstract

OBJECTIVE:

To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses.

METHODS:

The lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses.

RESULTS AND CONCLUSION:

The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7 ┬▒ 0.3 ┬Ámol/L.

PMID:
25057064
[Indexed for MEDLINE]
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