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Nat Rev Cancer. 2014 Aug;14(8):535-46. doi: 10.1038/nrc3775.

Non-small-cell lung cancers: a heterogeneous set of diseases.

Author information

1
1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. [2].
2
1] Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. [4].
3
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
4
1] Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
5
1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. [2] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

Erratum in

  • Nat Rev Cancer. 2015 Apr;15(4):247.

Abstract

Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have diverse pathological features. During the past decade, in-depth analyses of lung cancer genomes and signalling pathways have further defined NSCLCs as a group of distinct diseases with genetic and cellular heterogeneity. Consequently, an impressive list of potential therapeutic targets was unveiled, drastically altering the clinical evaluation and treatment of patients. Many targeted therapies have been developed with compelling clinical proofs of concept; however, treatment responses are typically short-lived. Further studies of the tumour microenvironment have uncovered new possible avenues to control this deadly disease, including immunotherapy.

PMID:
25056707
DOI:
10.1038/nrc3775
[Indexed for MEDLINE]
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