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AJR Am J Roentgenol. 2014 Aug;203(2):W158-65. doi: 10.2214/AJR.14.12518.

Use of high-resolution volumetric MR spectroscopic imaging in assessing treatment response of glioblastoma to an HDAC inhibitor.

Author information

1
1 Department of Radiology and Imaging Sciences, Emory University, 1701 Uppergate Dr, C5018, Atlanta, GA 30322.

Abstract

OBJECTIVE:

Improved predictive imaging would enable personalization and adjustment of treatment, which are critical for patients with glioblastomain whom therapy is likely to fail. This article describes the use of MR spectroscopic imaging (MRSI) to predict early clinical and behavioral response to a therapy and an effort to develop high-resolution, volumetric MRSI to improve its clinical application.

CONCLUSION:

MRSI may enable quantitative analysis of brain tumor response, offering a precise tool for monitoring of patients in clinical trials.

KEYWORDS:

MR spectroscopic imaging; epigenetic modification; glioblastoma; histone deacetylase (HDAC); vorinostat

PMID:
25055291
PMCID:
PMC4283208
DOI:
10.2214/AJR.14.12518
[Indexed for MEDLINE]
Free PMC Article

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