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CNS Oncol. 2014 Jan;3(1):61-75. doi: 10.2217/cns.13.66.

Brain metastases in non-small-cell lung cancer: better outcomes through current therapies and utilization of molecularly targeted approaches.

Author information

  • 1Department of Neurology, University of Chicago, Chicago, IL, USA. rlukas@neurology.bsd.uchicago.edu.

Abstract

Non-small-cell lung cancer (NSCLC) patients experience a high incidence of brain metastases, de novo and recurrent. We review the mechanisms of brain metastases and promising NSCLC molecular markers to delineate potential future therapeutic targets. Discussed are the current and previously utilized roles of surgery, radiation (both therapeutic and prophylactic), and systemic therapies in the treatment of NSCLC brain metastases. Future directions for treatment of NSCLC brain metastases will conclude our review.

PMID:
25054901
DOI:
10.2217/cns.13.66
[PubMed - indexed for MEDLINE]
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