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Biomed Rep. 2014 Sep;2(5):671-674. Epub 2014 May 26.

Anti-inflammatory effects of ozonated water in an experimental mouse model.

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Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
Sakuragawa Pump Co., Ltd., Osaka 567-0005, Japan.


Previous studies have suggested that ozonated water is safe and possesses antibacterial effects for treatment of experimental peritonitis rats. In this study, we evaluated the anti-inflammatory effects of ozonated water that was intraperitoneally injected into an experimental inflammatory mouse model. The concentrations of dissolved ozone decreased constantly and lineally, while the half-life of dissolved ozone was 36.8±2.7 min (27°C). The 10-ppm ozonated water was injected intraperitoneally into mice with lipopolysaccharide (LPS)-induced acute inflammation. The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor-α (TNF-α) and increased the activity of superoxide dismutase (SOD). The results suggest that ozonated water has anti-inflammatory properties and is a potential therapeutic option for acute inflammation.


anti-inflammatory; mouse; ozonated water; tumor necrosis factor-α

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