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Biomed Rep. 2014 Sep;2(5):649-652. Epub 2014 May 26.

Rat injury model of docetaxel extravasation.

Author information

1
Department of Rehabilitation, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University), Jinhua, Zhejiang 321000, P.R. China.
2
Department of Oncology, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University), Jinhua, Zhejiang 321000, P.R. China.
3
Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
4
Department of Pathology, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University), Jinhua, Zhejiang 321000, P.R. China.
5
Jinhua Food and Drug Administration, Jinhua, Zhejiang 321000, P.R. China.

Abstract

Docetaxel is a novel type of chemotherapy drug that actively treats a number of malignant tumors. The aim of the present study was to explore the severity and natural course of tissue damage induced by docetaxel extravasation and to confirm the vesicant potential of docetaxel. Rats were selected for the establishment of the ulcer model. Different volumes and concentrations were explored to induce the skin ulcer and to confirm the optimum rational injection model. The natural course of tissue injury and pathological changes produced by docetaxel extravasation were observed by comparing to vinorelbine extravasation. A 0.4 ml volume and a 6 mg/ml concentration were the optimum rational injection model for the induction of the skin ulcer. The docetaxel extravasation induced local tissue necrosis, followed by granuloma formation and hyperpigmentation or scar formation. The severity of the injury depended on the concentration of the extravasation used in the rat model. The injury occurred on the first day following extravasation and lasted 4-6 weeks. The damage from docetaxel was weaker than vinorelbine in association with the depth and extension of necrosis. In conclusion, docetaxel extravasation can induce tissue necrosis. However, the severity of necrosis was weaker than that of vinorelbine. Docetaxel has superficial vesicant properties.

KEYWORDS:

docetaxel; extravasation; pathology; skin toxicity

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