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Acta Med Indones. 2014 Apr;46(2):104-10.

Use of BRAF V600E as a molecular marker in aggressive colorectal cancer.

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1
Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Abstract

AIM:

to compare the immunoexpression of BRAF V600E among stage of colorectal cancer.

METHODS:

this was a cross sectional, and retrospective study involving Dukes' stage A, B, and C colorectal carcinoma, each with 15 cases. Immunohistochemistry was performed in paraffin-embedded specimens of tumor mass for the assessment of BRAF V600E. The proportion differences of immunoexpression of BRAF V600E among Dukes' stage A, B, and C were tested using Chi-Square test.

RESULTS:

the result of positive BRAF V600E immunoexpression (moderately to strongly positive) in Dukes' stage A, B, and C were found in 1 of 15 cases, 4 of 15 cases and 13 of 15 cases respectively. BRAF V600E immunoexpression was statistically significant more frequent in Dukes' stage C (p<0,001, Chi-Square test).

CONCLUSION:

positive BRAF V600E immunoexpression could be used as a marker of aggresive colorectal carcinoma.

PMID:
25053682
[Indexed for MEDLINE]
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