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Chin J Nat Med. 2014 Jul;12(7):495-9. doi: 10.1016/S1875-5364(14)60077-7.

Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats.

Author information

1
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Çapa, 34093, Istanbul, Turkey.
2
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Çapa, 34093, Istanbul, Turkey. Electronic address: gul_erata@yahoo.com.

Abstract

AIM:

Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats.

METHOD:

Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg(-1), orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg(-1)) every 12 h three times (binge model).

RESULTS:

Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg(-1)) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings.

CONCLUSION:

NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration.

KEYWORDS:

Binge ethanol; Liver; Nigella sativa; Oxidative stress; Rats

PMID:
25053547
DOI:
10.1016/S1875-5364(14)60077-7
[Indexed for MEDLINE]

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