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J Nutr Biochem. 2014 Oct;25(10):1077-83. doi: 10.1016/j.jnutbio.2014.05.010. Epub 2014 Jun 21.

Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation.

Author information

1
INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France.
2
Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France; CNRS, UMR 7339, Centre de Résonance Magnétique Biologique et Médicale, F-13385 Marseille, France.
3
INRA, UMR 1260, F-13385 Marseille, France; INSERM, UMR 1062, Nutrition, Obésité et Risque Thrombotique, F-13385 Marseille, France; Aix-Marseille Université Faculté de Médecine, F-13385 Marseille, France. Electronic address: jean-francois.landrier@univ-amu.fr.

Abstract

Prospective studies reported an inverse correlation between 25-hydroxyvitamin D [25(OH)D] plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25(OH)D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 (VD3) supplementation (15,000 IU/kg of food for 10 weeks) on onset of obesity in a diet-induced obesity mouse model. We showed that the VD3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure. Altogether, these data show that VD3 regulates energy expenditure and suggest that VD3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders.

KEYWORDS:

Adipose tissue; Adiposity; Micronutrients; Obesity; Preventive nutrition; Vitamin D

PMID:
25052163
DOI:
10.1016/j.jnutbio.2014.05.010
[Indexed for MEDLINE]

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