Centrosome duplication: suspending a license by phosphorylating a template

Kayoko Tanaka

doi:10.1016/j.cub.2014.06.008

Centrosome duplication: suspending a license by phosphorylating a template

Curr Biol. 2014 Jul 21;24(14):R651-R653. doi: 10.1016/j.cub.2014.06.008.

Author

Kayoko Tanaka¹

Affiliation

¹ Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK. Electronic address: kt96@le.ac.uk.

PMID: 25050963
DOI: 10.1016/j.cub.2014.06.008

Abstract

The phosphorylation status of Sfi1, a structural component of the yeast centrosome, governs the centrosome duplication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating Sfi1, which potentially acts as a template for a new centrosome.

Publication types

Comment

MeSH terms

CDC2 Protein Kinase / metabolism*
Cell Cycle / physiology*
Cell Cycle Proteins / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Repressor Proteins / metabolism*
Saccharomyces cerevisiae / physiology*
Saccharomyces cerevisiae Proteins / metabolism*
Spindle Pole Bodies / physiology*

Substances

Cell Cycle Proteins
Repressor Proteins
Saccharomyces cerevisiae Proteins
Protein Serine-Threonine Kinases
CDC2 Protein Kinase