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Nature. 1989 Aug 17;340(6234):521-4.

Sex in flies: the splice of life.

Author information

1
Department of Biological Sciences, Stanford University, California 94305.

Abstract

The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines sex, and thus the molecular biology of sex determination in the fruit-fly may lead to insights into the mechanisms by which alternative splicing is regulated.

PMID:
2505080
DOI:
10.1038/340521a0
[Indexed for MEDLINE]

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