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Neuroreport. 2014 Sep 10;25(13):1013-7. doi: 10.1097/WNR.0000000000000206.

Sound-induced hyperpolarization of hippocampal neurons.

Author information

1
aLaboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo bCenter for Information and Neural Networks, National Institute of Information and Communication Technology, Osaka, Japan.

Abstract

The hippocampus is involved in episodic memory, which is composed of subjective experiences in the multisensory world; however, little is known about the subthreshold membrane potential responses of individual hippocampal neurons to sensory stimuli. Using in-vivo whole-cell patch-clamp recordings from hippocampal CA1 neurons in awake mice, we found that almost all hippocampal neurons exhibited a hyperpolarization of 1-2 mV immediately after the onset of a sound. This large-scale hyperpolarization was unaffected by the duration or pitch of the tone. The response was abolished by general anesthesia and a surgical fimbria-fornix lesion.

PMID:
25050474
DOI:
10.1097/WNR.0000000000000206
[Indexed for MEDLINE]

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