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Oncoimmunology. 2014 Apr 17;3:e28500. eCollection 2014.

Discovering cancer immunotherapy targets in vivo.

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Dana-Farber Cancer Institute; Boston, MA USA.
Dana-Farber Cancer Institute; Boston, MA USA ; Program in Immunology; Harvard Medical School; Boston, MA USA.


A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.


RNAi screen; T cell; cancer; therapeutic targets; tumor microenvironment

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