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Oncoimmunology. 2014 Apr 17;3:e28499. eCollection 2014.

Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression.

Author information

1
Department of Radiation and Cellular Oncology; The Ludwig Center for Metastasis Research; University of Chicago, Chicago, IL USA.
2
Department of Pathology; University of Chicago, Chicago, IL USA.

Abstract

Tumor relapse after radiotherapy may be due to the upregulation of programmed cell death ligand 1 (PD-L1). We demonstrated that anti-PD-L1 antibody synergizes with radiation to control local and distal tumors. CD8+T cells mediated antitumor effects of the combination therapy by the reduction of myeloid-derived suppressor cells (MDSCs) via tumor-necrosis factor (TNF)-mediated signaling. Our study provides insight into immune- and radiation-based combinational therapies.

KEYWORDS:

PD-L1; T-cell activation; TNF; antibody therapy; myeloid-derived suppressor cell; negative signal; radiation therapy

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