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Inflamm Res. 2014 Oct;63(10):803-19. doi: 10.1007/s00011-014-0755-z. Epub 2014 Jul 22.

Inflammation and vitamin D: the infection connection.

Author information

1
Chronic Illness Recovery, Fort Worth, Texas, USA, info@chronicillnessrecovery.org.

Abstract

INTRODUCTION:

Inflammation is believed to be a contributing factor to many chronic diseases. The influence of vitamin D deficiency on inflammation is being explored but studies have not demonstrated a causative effect.

METHODS:

Low serum 25(OH)D is also found in healthy persons exposed to adequate sunlight. Despite increased vitamin D supplementation inflammatory diseases are increasing. The current method of determining vitamin D status may be at fault. The level of 25(OH)D does not always reflect the level of 1,25(OH)2D. Assessment of both metabolites often reveals elevated 1,25(OH)2D, indicating abnormal vitamin D endocrine function.

FINDINGS:

This article reviews vitamin D's influence on the immune system, examines the myths regarding vitamin D photosynthesis, discusses ways to accurately assess vitamin D status, describes the risks of supplementation, explains the effect of persistent infection on vitamin D metabolism and presents a novel immunotherapy which provides evidence of an infection connection to inflammation.

CONCLUSION:

Some authorities now believe that low 25(OH)D is a consequence of chronic inflammation rather than the cause. Research points to a bacterial etiology pathogenesis for an inflammatory disease process which results in high 1,25(OH)2D and low 25(OH)D. Immunotherapy, directed at eradicating persistent intracellular pathogens, corrects dysregulated vitamin D metabolism and resolves inflammatory symptoms.

PMID:
25048990
PMCID:
PMC4160567
DOI:
10.1007/s00011-014-0755-z
[Indexed for MEDLINE]
Free PMC Article

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