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Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130467. doi: 10.1098/rstb.2013.0467.

Causes and consequences of centrosome abnormalities in cancer.

Author information

1
Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK s.godinho@qmul.ac.uk.
2
Howard Hughes Medical Institute, Dana-Farber Cancer Institute, and Pediatric Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Pediatric Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Centrosome amplification is a hallmark of cancer. However, despite significant progress in recent years, we are still far from understanding how centrosome amplification affects tumorigenesis. Boveri's hypothesis formulated more than 100 years ago was that aneuploidy induced by centrosome amplification promoted tumorigenesis. Although the hypothesis remains appealing 100 years later, it is also clear that the role of centrosome amplification in cancer is more complex than initially thought. Here, we review how centrosome abnormalities are generated in cancer and the mechanisms cells employ to adapt to centrosome amplification, in particular centrosome clustering. We discuss the different mechanisms by which centrosome amplification could contribute to tumour progression and the new advances in the development of therapies that target cells with extra centrosomes.

KEYWORDS:

aneuploidy; cancer; centriole; centrosome amplification; clustering; microtubules

PMID:
25047621
PMCID:
PMC4113111
DOI:
10.1098/rstb.2013.0467
[Indexed for MEDLINE]
Free PMC Article

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