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Adv Mater. 2014 Sep 3;26(33):5815-22. doi: 10.1002/adma.201400941. Epub 2014 Jul 22.

Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification.

Author information

1
Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA; Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division for Biomedical Engineering, Division of Infectious Diseases, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.

Abstract

Current red-blood-cell cryopreservation methods utilize bulk volumes, causing cryo-injury of cells, which results in irreversible disruption of cell morphology, mechanics, and function. An innovative approach to preserve human red-blood-cell morphology, mechanics, and function following vitrification in nanoliter volumes is developed using a novel cryo-ink integrated with a bioprinting approach.

KEYWORDS:

bio-inspired materials; bio-printing; cryoprotective agents; nanoliter vitrification; red blood cell cryopreservation

PMID:
25047246
PMCID:
PMC4161503
DOI:
10.1002/adma.201400941
[Indexed for MEDLINE]
Free PMC Article

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