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Immunology. 1989 Aug;67(4):520-4.

Interferon-gamma as an adjuvant in immunocompromised mice.

Author information

1
Department of Immunology, U.C.S.M., London, U.K.

Abstract

We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody of low affinity, and mice depleted of CD4+ T cells. IFN-gamma and other cytokines may be safe adjuvants for use in human immunodeficiency states.

PMID:
2504662
PMCID:
PMC1385324
[Indexed for MEDLINE]
Free PMC Article

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