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Scientifica (Cairo). 2014;2014:768607. doi: 10.1155/2014/768607. Epub 2014 Jun 22.

The cardioprotective actions of hydrogen sulfide in acute myocardial infarction and heart failure.

Author information

1
Department of Pharmacology and Experimental Therapeutics and Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, LA 70112, USA.
2
Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
3
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

It has now become universally accepted that hydrogen sulfide (H2S), previously considered only as a lethal toxin, has robust cytoprotective actions in multiple organ systems. The diverse signaling profile of H2S impacts multiple pathways to exert cytoprotective actions in a number of pathological states. This paper will review the recently described cardioprotective actions of hydrogen sulfide in both myocardial ischemia/reperfusion injury and congestive heart failure.

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