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Biosci Microflora. 2011;30(4):129-33. doi: 10.12938/bifidus.30.129. Epub 2011 Nov 17.

Early probiotic supplementation for the prevention of atopic disease in newborns-probiotics and the hygiene hypothesis-.

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Department of Pediatrics, Epidemiology and Biostatistics and the Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, USA.


Environmental factors during early infancy could theoretically affect immune system development and subsequent risk of allergic disease. One potentially helpful exposure is early infant supplementation with specific probiotic strains. Unlike other exposures, probiotic supplementation is feasible and has a good safety profile. A review of recent randomized, controlled trials suggests that the effect of supplementation with probiotics on preventing the development of allergic disease is mixed. Further studies are needed to define potential mechanisms of action, such as effects on infant microbiota, as well as potential subgroups of patients that may benefit from these interventions.


Allergic Disease; Infant Microbiota; Probiotics; The Hygiene Hypothesis

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