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Placenta. 2014 Sep;35(9):780-3. doi: 10.1016/j.placenta.2014.07.003. Epub 2014 Jul 10.

Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia.

Author information

1
Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: brooke_matson@med.unc.edu.
2
Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: robert_corty@med.unc.edu.
3
Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: karpinic@email.unc.edu.
4
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: murth002@mc.duke.edu.
5
Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: william.valdar@unc.edu.
6
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: chad.grotegut@duke.edu.
7
Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA; Departments of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: kathleen_caron@med.unc.edu.

Abstract

Levels of the peptide hormone adrenomedullin (AM) are elevated during normal pregnancy, but whether this differs during complications of pregnancy remains unresolved. AM can be quantified by measuring its pre-prohormone byproduct, midregional pro-adrenomedullin (MR-proADM). MR-proADM has shown prognostic value as a biomarker of heart failure, sepsis, and community-acquired pneumonia. Given the relevance of AM to pregnancy, we tested the hypothesis that MR-proADM provides a biomarker for preeclampsia. We find that MR-proADM plasma concentrations are blunted in severe preeclampsia and that MR-proADM is similarly effective as established biomarkers endoglin and placental growth factor at discriminating patients with severe preeclampsia from controls.

KEYWORDS:

Adrenomedullin; Midregional pro-adrenomedullin; Preeclampsia; Pregnancy

PMID:
25043691
PMCID:
PMC4143458
DOI:
10.1016/j.placenta.2014.07.003
[Indexed for MEDLINE]
Free PMC Article
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