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Placenta. 2014 Sep;35(9):776-9. doi: 10.1016/j.placenta.2014.07.004. Epub 2014 Jul 10.

Surprising prenatal toxicity of epidermal lipoxygenase-3.

Author information

1
Department of Pediatrics, University of Erlangen-Nürnberg, Children's Hospital, 91054 Erlangen, Germany.
2
German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
3
Department of Obstetrics and Gynaecology, Laboratory for Molecular Medicine, University Hospital Erlangen, 91054 Erlangen, Germany.
4
Department of Pediatrics, University of Erlangen-Nürnberg, Children's Hospital, 91054 Erlangen, Germany. Electronic address: holm.schneider@uk-erlangen.de.

Abstract

Metabolites of the epidermal lipoxygenase-3 (eLOX-3) are involved in various metabolic pathways. Most unexpectedly, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, resulted in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression was altered. Thus, the observed prenatal toxicity of eLOX-3 could be due to a strong effect on placental development.

KEYWORDS:

Epidermal lipoxygenase; Fetal growth restriction; Glycogen trophoblast; Intrauterine death; Prenatal toxicity

PMID:
25043671
DOI:
10.1016/j.placenta.2014.07.004
[Indexed for MEDLINE]

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