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Nature. 2014 Jul 31;511(7511):551-6. doi: 10.1038/nature13442. Epub 2014 Jul 13.

Topoisomerase II mediates meiotic crossover interference.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
2
Department of Life Science, Chung-Ang University, Seoul 156-756, South Korea.

Abstract

Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classic phenomenon of crossover interference. Here we identify a molecular pathway for interference by analysing crossover patterns in budding yeast. Topoisomerase II plays a central role, thus identifying a new function for this critical molecule. SUMOylation (of topoisomerase II and axis component Red1) and ubiquitin-mediated removal of SUMOylated proteins are also required. The findings support the hypothesis that crossover interference involves accumulation, relief and redistribution of mechanical stress along the protein/DNA meshwork of meiotic chromosome axes, with topoisomerase II required to adjust spatial relationships among DNA segments.

PMID:
25043020
PMCID:
PMC4128387
DOI:
10.1038/nature13442
[Indexed for MEDLINE]
Free PMC Article

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