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Trends Microbiol. 2014 Sep;22(9):498-507. doi: 10.1016/j.tim.2014.06.004. Epub 2014 Jul 17.

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.

Author information

1
Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Microbiologie de la Méditerranée, CNRS UMR7255, Aix-Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France; Architecture et Fonction des Macromolécules Biologiques, CNRS UMR7257, Aix-Marseille Université, Campus de Luminy, Case 932, 13288 Marseille Cedex 09, France.
2
Architecture et Fonction des Macromolécules Biologiques, CNRS UMR7257, Aix-Marseille Université, Campus de Luminy, Case 932, 13288 Marseille Cedex 09, France.
3
Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Microbiologie de la Méditerranée, CNRS UMR7255, Aix-Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. Electronic address: cascales@imm.cnrs.fr.
4
Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Microbiologie de la Méditerranée, CNRS UMR7255, Aix-Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. Electronic address: ljournet@imm.cnrs.fr.

Abstract

The type VI secretion system (T6SS) is a macromolecular machine that delivers protein effectors into both prokaryotic and eukaryotic cells, therefore participating in interbacterial competition and virulence. The T6SS is functionally and structurally similar to the contractile bacteriophage cell puncturing device: the contraction of a sheath-like structure is believed to propel an inner tube terminated by a spike towards target cells, allowing the delivery of effectors. In this review, we summarize recent advances in the identification and characterization of T6SS effector proteins, highlighting the broad repertoire of enzymatic activities, and discuss recent findings relating to the secretion mechanisms.

KEYWORDS:

actin cross-linking; amidase; phospholipase; protein secretion; toxins

PMID:
25042941
DOI:
10.1016/j.tim.2014.06.004
[Indexed for MEDLINE]

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