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J Dermatol. 2014 Aug;41(8):746-8. doi: 10.1111/1346-8138.12563. Epub 2014 Jul 16.

Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.

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Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.


Matrix metalloproteinase-13 (MMP-13), a member of the collagenase family, has been implicated in the pathogenesis of connective tissue diseases characterized by extracellular matrix remodeling. Since serum MMP-13 levels reflect disease severity of systemic sclerosis and localized scleroderma, we evaluated the clinical significance of serum MMP-13 levels in eosinophilic fasciitis (EF). All the EF patients had serum MMP-13 levels lower than the mean - 2SD of healthy controls. Serum MMP-13 levels were also significantly decreased in EF patients compared with diffuse cutaneous systemic sclerosis, limited cutaneous systemic sclerosis, and generalized morphea patients. Although serum MMP-13 levels did not reflect any clinical and serological features of EF, these results indicate that MMP-13 may be involved in the development of this disease.


eosinophilic fasciitis; extracellular matrix; fibrosis; matrix metalloproteinase-13; scleroderma

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