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Clin Microbiol Infect. 2014 Aug;20(8):717-23. doi: 10.1111/1469-0691.12761.

Norovirus infection in immunocompromised hosts.

Author information

1
Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Abstract

Acute gastroenteritis caused by noroviruses often has a duration of 2-3 days and is characteristically self-limiting. In contrast, chronic infection caused by noroviruses in immunocompromised individuals can last from weeks to years, making clinical management difficult. The mechanisms by which noroviruses establish persistent infection, and the role of immunocompromised hosts as a reservoir for noroviruses in the general human population, are not known. However, study of this patient cohort may lead to new insights into norovirus biology and approaches to treatment.

KEYWORDS:

Acquired immunodeficiency; chronic infection; immunocompromised; immunosuppressed; norovirus

PMID:
25040790
DOI:
10.1111/1469-0691.12761
[Indexed for MEDLINE]
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