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J Periodontal Res. 2015 Apr;50(2):274-80. doi: 10.1111/jre.12207. Epub 2014 Jul 7.

Low serum level of 1,25(OH)2 D is associated with chronic periodontitis.

Author information

1
Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu, Finland.

Abstract

BACKGROUND AND OBJECTIVES:

Vitamin D has been studied primarily for its involvement in calcium and phosphate absorption and bone metabolism. The active form of vitamin D-1,25(OH)2 D-has also been investigated for its immune modulatory properties. We explored associations between serum levels of 25(OH)D and 1,25(OH)2 D and periodontal health.

SUBJECTS AND METHODS:

This case-control study included 55 subjects with chronic periodontitis (cases) and 30 periodontally healthy subjects (controls). Their serum levels of 25(OH)D, 1,25(OH)2 D, ultrasensitive C-reactive protein and high-density lipoprotein cholesterol were determined. Associations between vitamin D and periodontal health status were studied using logistic regression analysis.

RESULTS:

A statistically significant association was found between serum 1,25(OH)2 D level and periodontal health status; in that subjects with a low 1,25(OH)2 D were more likely to belong to the periodontitis group (OR = 0.97, 95% CI = 0.95-1.00). There was practically no association between 25(OH)D level and periodontal health status.

CONCLUSION:

In this case-control study low serum 1,25(OH)2 D level appeared to be associated with periodontitis, which was in line with the previously reported associations between serum 1,25(OH)2 D levels and other inflammatory diseases. Whether this association is causal in nature, remains to be confirmed in future studies.

KEYWORDS:

calcifediol; calcitriol; inflammation; periodontitis; serum

PMID:
25039942
DOI:
10.1111/jre.12207
[Indexed for MEDLINE]

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