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Int Immunopharmacol. 2014 Oct;22(2):341-5. doi: 10.1016/j.intimp.2014.07.005. Epub 2014 Jul 16.

Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice.

Author information

1
Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
2
Department of Gastroenterology Surgery, Renji Hospital School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: renjizhouhong@163.com.

Abstract

Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic acid on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice. The results showed that LPS/GalN increased hepatic malondialdehyde (MDA) content, TNF-α level, serum ALT and AST levels and TNF-α level. However, these changes were attenuated by ellagic acid. Western blot analysis showed that ellagic acid inhibited LPS/GalN-induced NF-κB activation. Furthermore, ellagic acid induced the expression of Nrf2 and heme oxygenase-1. In conclusion, our results showed that ellagic acid protected against LPS/GalN-induced liver injury by enhancing the antioxidative defense system and reducing inflammatory response.

KEYWORDS:

Ellagic acid; Lipopolysaccharide (LPS); NF-κB; Nrf2

PMID:
25038320
DOI:
10.1016/j.intimp.2014.07.005
[Indexed for MEDLINE]

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