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Ann Epidemiol. 2014 Sep;24(9):629-34, 634.e1. doi: 10.1016/j.annepidem.2014.05.010. Epub 2014 May 23.

Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems.

Author information

1
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington.
2
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
3
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington. Electronic address: bmdonofr@indiana.edu.

Abstract

PURPOSE:

Parental severe mental illness (SMI) is associated with an increased risk of offspring autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We conducted a study to examine the extent to which risk of preterm birth, low birth weight, and small for gestational age mediated this association.

METHODS:

We obtained data on offspring born 1992-2001 in Sweden (n = 870,017) through the linkage of multiple population-based registers. We used logistic and Cox regression to assess the associations between parental SMI, adverse pregnancy outcomes, and offspring ASD and ADHD, as well as tested whether adverse pregnancy outcomes served as mediators.

RESULTS:

After controlling for measured covariates, maternal and paternal SMI were associated with an increased risk for preterm birth, low birth weight, and gestational age, and for offspring ASD and ADHD. These pregnancy outcomes were also associated with an increased risk of ASD and ADHD. We found that pregnancy outcomes did not mediate the association between parental SMI and offspring ASD and ADHD, as there was no substantial change in magnitude of the risk estimates after controlling for pregnancy outcomes.

CONCLUSIONS:

Parental SMI and adverse pregnancy outcomes appear to be independent risk factors for offspring ASD and ADHD.

KEYWORDS:

Attention deficit hyperactivity disorder; Autism spectrum disorder; Birth weight; Gestational age; Infant; Small for gestational age

PMID:
25037304
PMCID:
PMC4135008
DOI:
10.1016/j.annepidem.2014.05.010
[Indexed for MEDLINE]
Free PMC Article

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