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J Neuroimmunol. 2014 Sep 15;274(1-2):180-4. doi: 10.1016/j.jneuroim.2014.06.026. Epub 2014 Jul 6.

Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population.

Author information

  • 1Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China.
  • 2Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China; Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China; Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.. Electronic address: dr.tanlan@163.com.
  • 3Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.
  • 4Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
  • 5Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, China; Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China; Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.. Electronic address: yu-jintai@163.com.

Abstract

As a pro-inflammatory cytokine belonging to the interleukin (IL)-1 family, IL-12 is recently found to be involved in the pathogenesis of Alzheimer's disease (AD). Here, we investigated the relations of three potentially functional single nucleotide polymorphisms (SNPs) in IL-12A (rs2243115 and rs568408) and IL-12B (rs3212227) with late-onset AD (LOAD) risk in a Northern Han Chinese cohort containing 1133 patients and 1158 healthy controls. Our findings indicated that these SNPs in IL-12A and IL-12B can individually and jointly contribute to LOAD risk in Han Chinese, implying that the genes encoding IL-12 subunits represent novel genetic risk factors for LOAD susceptibility.

KEYWORDS:

Alzheimer's disease; Association; Gene; IL-12; Polymorphism; Pro-inflammatory cytokine

PMID:
25037175
DOI:
10.1016/j.jneuroim.2014.06.026
[PubMed - indexed for MEDLINE]
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