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Neurol Clin. 2014 Aug;32(3):629-46, vii. doi: 10.1016/j.ncl.2014.04.001. Epub 2014 Jun 6.

Inclusion body myositis.

Author information

1
Neuromuscular Section, Neurophysiology Division, Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 2012, Kansas City, KS 66160, USA. Electronic address: mdimachkie@kumc.edu.
2
Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 2012, Kansas City, KS 66160, USA.

Abstract

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecrotic muscle fibers often accompanied by rimmed vacuoles and protein deposits. It is likely that IBM is has a prominent degenerative component. This article reviews the evolution of knowledge in IBM, with emphasis on recent developments in the field, and discusses ongoing clinical trials.

KEYWORDS:

Diagnosis; Idiopathic inflammatory myopathies; Inclusion body myositis; Pathology; Pathophysiology; Polymyositis; Prognosis; Treatment

PMID:
25037082
PMCID:
PMC4115580
DOI:
10.1016/j.ncl.2014.04.001
[Indexed for MEDLINE]
Free PMC Article

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