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Mech Ageing Dev. 2014 Sep;140:10-2. doi: 10.1016/j.mad.2014.07.001. Epub 2014 Jul 15.

Dietary advanced glycation end products are associated with decline in memory in young elderly.

Author information

1
The Icahn School of Medicine at Mount Sinai, New York, NY, US. Electronic address: rebecca.west@mssm.edu.
2
The Icahn School of Medicine at Mount Sinai, New York, NY, US.
3
The Sheba Medical Center, The Joseph Sagol Neuroscience Center, Ramat Gan, Israel.
4
The Icahn School of Medicine at Mount Sinai, New York, NY, US; The James J Peters Veterans Affairs Medical Center, Bronx, NY, US.
5
The Icahn School of Medicine at Mount Sinai, New York, NY, US; The Sheba Medical Center, The Joseph Sagol Neuroscience Center, Ramat Gan, Israel.

Abstract

We recently reported that serum methylglyoxal (sMG) is associated with a faster rate of decline in a global measure of cognition in the very elderly. We here provide for the first time evidence in which high levels of dietary AGE (dAGE) are associated with faster rate of decline in memory in 49 initially non-demented young elderly (p=0.012 in mixed regression models adjusting for sociodemographic and cardiovascular factors). Since modifying the levels of AGEs in the diet may be relatively easy, these preliminary results suggest a simple strategy to diminish cognitive compromise in the elderly and warrant further investigation.

KEYWORDS:

Cognitive decline; Dietary advanced glycation end products; Memory; Methylglyoxal; Type 2 diabetes

PMID:
25037023
PMCID:
PMC4167353
DOI:
10.1016/j.mad.2014.07.001
[Indexed for MEDLINE]
Free PMC Article

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