Format

Send to

Choose Destination
Environ Res. 2014 Aug;133:348-52. doi: 10.1016/j.envres.2014.06.009. Epub 2014 Jul 16.

Serum levels of monobenzylphthalate (MBzP) is related to carotid atherosclerosis in the elderly.

Author information

1
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Electronic address: bernice.wiberg@akademiska.se.
2
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
3
Department of Medicine, Uppsala University, Uppsala, Sweden.

Abstract

BACKGROUND AND OBJECTIVE:

Background exposure to environmental contaminants has recently emerged as a new risk factor for cardiovascular disease in general and to atheroclerosis in particular. This cross-sectional study was performed to evaluate if serum concentrations of the phthalate metabolite monobenzylphthalate (MBzP) are related to atheroclerosis in the carotid arteries.

METHODS:

In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1003 subjects all aged 70) the prevalence of overt plaques and echogenicity (gray-scale median, GSM) of carotid artery plaques were recorded by ultrasound in both of the carotid arteries. The intima-media thickness (IMT) and echogenicity (IM-GSM) of the intima-media complex were also measured. The phthalate metabolite MBzP was analyzed in serum by a liquid chromatograph/tandem mass spectrometer.

RESULTS:

The circulating level of the phthalate MBzP was related to intima-media thickness (IMT) when adjusting for gender, blood pressure, body mass index (BMI), waist circumference, HDL- and LDL-cholesterol, serum triglycerides, blood glucose and smoking (p=0.034). High levels of MBzP were also strongly associated with an echogenic IM-GSM and plaque GSM (p=0.0001 for both outcomes after adjustment) but not to plaque prevalence (p=0.42).

CONCLUSION:

The phthalate metabolite MBzP was strongly related to the echogenicity of intima-media and plaques and also to IMT, independently of traditional CV risk factors. This suggests a role for the phthalate MBzP in the development of atherosclerosis.

KEYWORDS:

Atherosclerosis; Carotids; Endocrine disruptor; Intima media thickness; Phthalate

PMID:
25036990
DOI:
10.1016/j.envres.2014.06.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center