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Chem Biol. 2014 Jul 17;21(7):803-4. doi: 10.1016/j.chembiol.2014.07.002.

Tracking hippo in the cancer jungle.

Author information

1
Children's Hospital Oakland Research Institute, UCSF Benioff Children's Hospital Oakland, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA.
2
Children's Hospital Oakland Research Institute, UCSF Benioff Children's Hospital Oakland, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA. Electronic address: jsaba@chori.org.

Abstract

Signaling through the Hippo pathway controls major aspects of cell growth and proliferation. Focusing on the metabolic consequences of Hippo signaling, Mulvihill and colleagues in this issue of Chemistry & Biology employ a large scale, integrative approach and uncover downstream reorganization of cellular metabolism when the effector TAZ is upregulated, identifying new connections to lipid metabolism.

PMID:
25036773
DOI:
10.1016/j.chembiol.2014.07.002
[Indexed for MEDLINE]
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