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Cell. 2014 Jul 17;158(2):247-249. doi: 10.1016/j.cell.2014.06.043.

γ-Secretase: a horseshoe structure brings good luck.

Author information

1
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mswolfe@partners.org.
2
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dselkoe@partners.org.

Abstract

The intramembrane protease γ-secretase is a key player in signaling and Alzheimer's disease, but its structural features have remained obscure. A structure reported recently reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognition. This advance bodes well for a finer resolution before long.

PMID:
25036627
DOI:
10.1016/j.cell.2014.06.043
[Indexed for MEDLINE]
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