Format

Send to

Choose Destination
Crit Rev Clin Lab Sci. 2014 Dec;51(6):305-20. doi: 10.3109/10408363.2014.937522. Epub 2014 Jul 18.

Relevance of microRNA in metabolic diseases.

Author information

1
Vascular Biology and Therapeutics Program and.

Abstract

Metabolic syndrome is a complex metabolic condition caused by abnormal adipose deposition and function, dyslipidemia and hyperglycemia, which affects >47 million American adults and ∼1 million children. Individuals with the metabolic syndrome have essentially twice the risk for developing cardiovascular disease (CVD) and Type 2 diabetes mellitus (T2D), compared to those without the syndrome. In the search for improved and novel therapeutic strategies, microRNAs (miRNA) have been shown to be interesting targets due to their regulatory role on gene networks controlling different crucial aspects of metabolism, including lipid and glucose homeostasis. More recently, the discovery of circulating miRNAs suggest that miRNAs may be involved in facilitating metabolic crosstalk between organs as well as serving as novel biomarkers of diseases, including T2D and atherosclerosis. These findings highlight the importance of miRNAs for regulating pathways that underlie metabolic diseases, and their potential as therapeutic targets for the development of novel treatments.

KEYWORDS:

Atherosclerosis; metabolic syndrome; microRNAs

PMID:
25034902
DOI:
10.3109/10408363.2014.937522
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center