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Aging Clin Exp Res. 2015 Apr;27(2):239-42. doi: 10.1007/s40520-014-0261-8. Epub 2014 Jul 18.

Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA).

Author information

1
The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Lincoln Gate, Dublin 2, Republic of Ireland, romeror@tcd.ie.

Abstract

BACKGROUND:

Orthostatic hemodynamic signals may predict adverse outcomes in elders.

AIMS:

To study the association between orthostatic hemodynamics and incident mortality in The Irish Longitudinal Study on Ageing (TILDA).

METHODS:

Wave 1 subjects underwent an active stand with non-invasive beat-to-beat blood pressure monitoring. We compared wave 1 active stands, dead vs alive in wave 2.

RESULTS:

Compared to the 4,415 participants who had not died, the 53 who had died had a higher baseline heart rate [HR mean of 69 vs 65 beats per minute (bpm)] and a higher mean orthostatic HR, especially between 30 and 60 s post-stand (mean of 79 vs 73 bpm). After adjusting for age, sex, baseline HR, mini-mental state examination score and cardiovascular comorbidities and medications, the mean HR between 30 and 60 s post-stand independently predicted mortality (baseline HR did not).

DISCUSSION:

Higher early orthostatic HR may be an independent risk marker. Further validation is required.

PMID:
25034834
DOI:
10.1007/s40520-014-0261-8
[Indexed for MEDLINE]

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