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Clin Breast Cancer. 2014 Dec;14(6):390-5. doi: 10.1016/j.clbc.2014.06.002. Epub 2014 Jun 23.

Breast cancer in adolescent and young adult women.

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Faculty of Applied Medical Science, Misr University for Science and Technology, Cairo, Egypt.
Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ. Electronic address:


Breast cancer is one of the most frequently diagnosed malignancy among adolescent and young adult (AYA) women, accounting for approximately 14% of all AYA cancer diagnoses and 7% of all breast cancer. Breast cancer in AYA women is believed to represent a more biologically aggressive disease, but aside from commonly known hereditary predispositions, little is still known about the underlying molecular genetic causes. This review examines the current trends of breast cancer in AYA women as they relate to clinical, social, genetic, and molecular pathologic characteristics. We highlight existing trends, treatment and imaging approaches, and health burdens as they relate to breast cancer in AYA women and provide a discussion on ways to help improve the overall management of this breast cancer cohort.


Adolescent and young adult; Breast cancer; Family history; Imaging; Treatment

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