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J Clin Virol. 2014 Sep;61(1):113-7. doi: 10.1016/j.jcv.2014.05.020. Epub 2014 Jun 28.

Multicenter clinical performance evaluation of BD Veritor™ system for rapid detection of respiratory syncytial virus.

Author information

1
Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, United States; University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States.
2
Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
3
Penn State University College of Medicine, Hershey, PA, United States; Penn State Hershey Medical Center, Hershey, PA, United States.
4
University of Arkansas for Medical Sciences, Little Rock, AR, United States; Arkansas Children's Hospital, Little Rock, AR, United States.
5
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.
6
Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, United States; University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States. Electronic address: rselvarangan@cmh.edu.

Abstract

BACKGROUND:

BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus (RSV) is a new-generation lateral flow immunochromatographic assay for objective detection of RSV in respiratory specimens from children.

OBJECTIVE:

To evaluate the performance of BD Veritor™ System for Rapid Detection of RSV in respiratory specimens collected from pediatric patients.

STUDY DESIGN:

A prospective, multicenter clinical trial was undertaken at five study sites representing geographically diverse regions of the U.S. to assess the performance of the BD Veritor™ System for Rapid Detection of RSV in comparison to R-mix shell vial culture and ProFlu+ reverse transcription-PCR assay (Gen-Probe/Prodesse).

RESULTS:

440 nasopharyngeal washes/aspirates (NPW/A) and 706 nasopharyngeal swab (NPS) specimens from U.S. subjects<20 years of age were collected and tested using the BD Veritor™ System and compared with shell vial culture and real-time RT-PCR results. Analysis of the data indicates the overall sensitivity and specificity for BD Veritor™ System for all sample types combined was 90% and 97.0% versus shell vial culture and 75.5% and 98.7% versus RT-PCR respectively.

CONCLUSION:

Overall, the BD Veritor™ System for the Rapid Detection of RSV performed well when compared to both viral cell culture and RT-PCR in children.

KEYWORDS:

Antigen; BD Veritor; Children; PCR; RSV

PMID:
25034375
DOI:
10.1016/j.jcv.2014.05.020
[Indexed for MEDLINE]
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