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J Clin Endocrinol Metab. 2014 Nov;99(11):4336-45. doi: 10.1210/jc.2014-1742. Epub 2014 Jul 17.

The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.

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Department of Public Health (C.B., F.B., V.R., J.S., J-Y.R., O.B.), Epidemiology and Health Economics, University of Liège, Liège, Belgium; Support Unit in Epidemiology and Biostatistics (C.B., F.B., J.S., J-Y.R., O.B.), University of Liège, Belgium; Geriatric Department (S.G., J.P.), CHU Liège, Liège, Belgium; Department of Clinical Chemistry (E.C.), University of Liège, CHU Sart-Tilman, Liège, Belgium; Bone and Cartilage Metabolism Department (J-Y.R.), CHU Liège, Liège, Belgium; and Department of Motricity Sciences (O.B.), University of Liège, Liège, Belgium.



There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle.


The aim was to summarize with a meta-analysis, the effects of vitamin D supplementation on muscle function.


A systematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts.


All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria.


Data were extracted by two independent reviewers.


Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (P = .02). No significant effect was found on muscle mass (SMD 0.058; P = .52) or muscle power (SMD 0.057; P = .657). Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level <30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 vs SMD 0.03; 95% CI -0.08 to 0.14).


Vitamin D supplementation has a small positive impact on muscle strength, but additional studies are needed to define optimal treatment modalities, including dose, mode of administration, and duration.

[Indexed for MEDLINE]

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