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Biomed Res Int. 2014;2014:530687. doi: 10.1155/2014/530687. Epub 2014 Jun 18.

Strontium chloride: can it be a new treatment option for ulcerative colitis?

Author information

1
Gastroenterology Clinic, Ataturk Training and Research Hospital, 35965 Izmir, Turkey.
2
Department of Gastroenterology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey ; Cumhuriyet Universitesi Hastanesi, Gastroenteroloji B.D., 58140 Sivas, Turkey.
3
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Cumhuriyet University, 58140 Sivas, Turkey.
4
Department of Pathology, Faculty of Veterinary Medicine, Cumhuriyet University, 58140 Sivas, Turkey.
5
Gastroenterology Clinic, Anadolu Hospital, 58070 Sivas, Turkey.
6
Department of Dermatology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey.

Abstract

BACKGROUND/AIMS:

Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap and can be given orally. We for the first time aimed to investigate the effect of strontium chloride (SrCl2) on inflammation in experimental colitis.

METHODS:

Thirty female Wistar albino rats were divided into 5 groups each containing 6 rats. The rats in groups 1 and 2 served as the healthy control and colitis group, respectively. The rats in groups 3, 4, and 5 had colitis and received 40 mg/kg SrCl2, 160 mg/kg SrCl2, and 1 mg/kg prednisolone by oral gavage, respectively. The rats were sacrificed for histological evaluation and determination of serum neopterin, TNF-α, and IFN-γ levels.

RESULTS:

The neopterin, TNF-α and IFNγ levels of group 2 was significantly higher than the other groups. The neopterin, TNF-α, and IFN-γ levels of controls and other treatment groups were comparable. There were a significant difference in macroscopic and microscopic healing between group 2 and other groups histologically. But there was not a significant difference within treatment receiving groups.

CONCLUSION:

SrCl2 had comparable therapeutic efficiency with prednisolone.

PMID:
25032214
PMCID:
PMC4086370
DOI:
10.1155/2014/530687
[Indexed for MEDLINE]
Free PMC Article

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