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Nephrourol Mon. 2014 May 10;6(3):e16870. doi: 10.5812/numonthly.16870. eCollection 2014 May.

Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration.

Author information

1
Department of Urology, Hisar Intercontinental Hospital, Istanbul, Turkey.
2
Department of Urology, Sabuncuoglu Serefeddin Training and Research Hospital, Amasya, Turkey.
3
Department of Infectious Disease and Clinical Microbiology, Hisar Intercontinental Hospital, Istanbul, Turkey.
4
Department of Clinical Biochemistry, Hisar Intercontinental Hospital, Istanbul, Turkey.

Abstract

BACKGROUND:

Considering all the couples willing and trying to get pregnant, the incidence of infertility is 15% of which approximately half of the cases are due to the male factors.

OBJECTIVES:

The aim of this study was the investigation of the effects of ubiquinol, reduced form of coenzyme Q10 (Co-Q10), an empiric treatment modality, on sperm parameters in idiopathic subfertility.

PATIENTS AND METHODS:

In this retrospective study, 62 patients who had received 100 mg ubiquinol twice a day for six months due to idiopathic infertility since January 2012 to January 2013 were included. Only infertile patients with astheno-teratozoospermia without any identified etiology and with a spermatozoa concentration of greater than 13 × 10(6)/mL were included.

RESULTS:

The increase in mean values of concentration after the ubiquinol treatment was not statistically significant (P value = 0.065). However, the changes in morphology and motility (fast progressive [a] and a + slow progressive [b]) were statistically significant (P < 0.00).

CONCLUSIONS:

The weakness of the literature with regard to coenzyme Q10 is about its effects in patients with severely diminished sperm densities and the physiologic steps of morphologic improvements.

KEYWORDS:

Idiopathic; Infertility; Oligospermia; Ubiquinol

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