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Genome Med. 2014 Jun 9;6(6):124. doi: 10.1186/gm561. eCollection 2014.

Why epistasis is important for tackling complex human disease genetics.

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Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03756, USA.


Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease.

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