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Genes Dev. 2014 Jul 15;28(14):1517-32. doi: 10.1101/gad.244772.114.

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.

Author information

1
de Duve Institute and Université Catholique de Louvain, B-1200 Brussels, Belgium;
2
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA.

Abstract

In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but how and for what purposes have been matters of much debate. In this review, we summarize our current knowledge of Wnt/β-catenin signaling and its downstream transcriptional regulators in normal and malignant stem cells. We centered this review largely on three types of stem cells--embryonic stem cells, hair follicle stem cells, and intestinal epithelial stem cells--in which the roles of Wnt/β-catenin have been extensively studied. Using these models, we unravel how many controversial issues surrounding Wnt signaling have been resolved by dissecting the diversity of its downstream circuitry and effectors, often leading to opposite outcomes of Wnt/β-catenin-mediated regulation and differences rooted in stage- and context-dependent effects.

KEYWORDS:

LEF/TCF; Wnt signaling; stem cells; β-catenin

PMID:
25030692
PMCID:
PMC4102759
DOI:
10.1101/gad.244772.114
[Indexed for MEDLINE]
Free PMC Article

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