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Nanoscale. 2014 Aug 21;6(16):9599-603. doi: 10.1039/c4nr02711f.

Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions.

Author information

1
Dipartimento di Scienze Biomediche, Università degli studi di Sassari, 07100 Sassari, Italy.

Abstract

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

PMID:
25029354
DOI:
10.1039/c4nr02711f
[Indexed for MEDLINE]

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