Format

Send to

Choose Destination
Nature. 1989 Aug 3;340(6232):363-7.

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen.

Author information

1
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Genetik, Tübingen, FRG.

Abstract

The maternal gene bicoid is a key component of the system that determines the pattern of the anterior half of Drosophila embryos. The bicoid protein forms a concentration gradient in early embryos, and is known to bind DNA. Specific binding sites are now shown to confer expression in a region of the embryo that depends on their affinity for bicoid protein: sites of high affinity allow expression further down the bicoid protein gradient than sites of low affinity.

PMID:
2502714
DOI:
10.1038/340363a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center